Tranexamic Acid for Skin

Tranexamic acid (TXA), a lysine derivative and antifibrinolytic, demonstrates significant dermatological benefits. In psoriasis models, TXA reduces erythema, thickness, scaling, hyperkeratosis, and inflammation, suppressing NFκB and NLRP3 inflammasome pathways, while enhancing autophagy and downregulating keratin 17. Clinically, TXA is effective for melasma, acne, rosacea, post-inflammatory hyperpigmentation, and angioedema due to its anti-inflammatory, anti-angiogenic, and melanogenesis-inhibiting properties. It can be administered orally, topically, or via intradermal injection, alone or with other therapies, highlighting its versatile and promising role in dermatological treatments.

Publications

• Tranexamic Acid Improves Psoriasis-Like Skin Inflammation: Evidence from In Vivo and In Vitro Studies; Jhih-Hsuan Hseu, Chon-I Chan, Chithravel Vadivalagan, et al.; Biomedicine & Pharmacotherapy, 2023; DOI: 10.1016/j.biopha.2023.115307
• The Use of Tranexamic Acid in Dermatology; Klara Gaćina, Anđela Krstanović Ćosić; Acta Clinica Croatica, Vol. 62(2), 368–372, 2023