PDRN for Skin

Polydeoxyribonucleotides (PDRNs) are low molecular weight DNA-derived molecules that support tissue regeneration and wound healing. Research shows they enhance cell migration and growth, stimulate extracellular matrix protein production, promote angiogenesis, and reduce inflammation through adenosine A₂A receptor activation. PDRNs have demonstrated benefits in skin rejuvenation, impaired wound healing, and musculoskeletal tissue repair, improving healing time, tissue quality, and reducing pain. Derived from sources like salmon sperm, they are considered safe, with ongoing studies aiming to standardize dosages and expand clinical applications.

Publications

• Polydeoxyribonucleotides (PDRNs) From Skin to Musculoskeletal Tissue Regeneration via Adenosine A(2A) Receptor Involvement; Veronesi F, Dallari D, Sabbioni G, et al.; Journal of Cellular Physiology, Vol. 232(9)
• Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing; Galeano M, Pallio G, Irrera N, et al.; Pharmaceuticals (Basel, Switzerland), Vol. 14(11)
• From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules; Marques C, Porcello A, Cerrano M, et al.; Biomolecules, Vol. 15(1)
• Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering; Kim TH, Heo SY, Oh GW, et al.; Marine Drugs, Vol. 19(6)