Research Publications on Sage

First time proof of sage’s tolerability and efficacy in menopausal women with hot flushes; Advances in Therapy, 2011; Link

This clinical trial explored the effectiveness and tolerability of fresh sage (Salvia officinalis) in managing hot flushes and other menopausal complaints, marking a novel investigation into its traditional use for menopausal symptoms. Conducted across eight Swiss practices, the study involved 71 menopausal patients who had been experiencing at least five daily flushes. Over an 8-week period, participants were administered a daily tablet of fresh sage leaves, with outcomes measured by changes in the intensity and frequency of hot flushes, and a comprehensive assessment using the Menopause Rating Scale (MRS). The results showed a significant reduction in hot flushes — with a 50% decrease observed within 4 weeks and a 64% decrease by 8 weeks. Additionally, there was a notable decline in the severity of flushes and improvements across all subscales of the MRS. The study concluded that fresh sage is an effective and well-tolerated treatment for hot flushes and related menopausal symptoms, presenting a promising nonhormonal option for menopausal women.